Sexual desire and arousal in postmenopausal women

Research status

Completed

Overview of Study

A multicentre, randomised, double blind, double dummy, comparative group study, to compare the effects of tibolone and transdermal continuous combined estradiol/norethisterone on the vaginal bleeding pattern, sexual desire and arousal in postmenopausal women with sexual dysfunction.

Objectives of study

The aim of this 6 month study was to assess the effects of tibolone (Livial ®) and transdermal continuous combined estradiol/norethisterone (Estalis®) on the vaginal bleeding pattern, sexual desire and arousal in postmenopausal women.  

This study's participants were healthy, postmenopausal women who: 

  • were aged between 48 and 68 years of age
  • were in an established relationship of at least 6 months
  • had not had a period for 6 months
  • had noticed a change in their sex lives compared to their younger years

Eligible women were randomised into either being treated with a patch containing study drug and a tablet containing placebo or a tablet containing study drug and a patch containing placebo.  The tablets were taken by the participants once a day and a new patch was applied to the abdomen twice a week. Subjects attended  four monitoring visits during the course of the study visit and they also completed qualitative questionnaires.

Eligible women were randomised into either being treated with a patch containing study drug and a tablet containing placebo or a tablet containing study drug and a patch containing placebo.  The tablets were taken by the participants once a day and a new patch was applied to the abdomen twice a week. Subjects attended  four monitoring visits during the course of the study visit and they also completed qualitative questionnaires.

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